The 6 Most Common Cleanroom Cleaning Solutions

Sep 20, 2018 7:00:00 AM / by The Pegasus Team

When it comes to cleanroom cleaning solutions, ensuring you pick the right products is crucial. You need to know which solutions will meet your cleanroom standards to remain compliant with regulations. For different materials, you’ll need different solutions. For different types of cleanrooms, you’ll need different solutions. For different stages of the cleaning process, you’ll need different solutions. Remember: cleaning and disinfecting are not the same. Both are necessary, and both require different types of cleanroom cleaning solutions.

Cleaners vs. Disinfectors

You need to clean your surfaces with detergents before you disinfect them with chemicals.

Detergents should be neutral, non-ionic, and non-foaming. Be sure also that your detergent’s cleaning properties won’t inhibit your chemical’s disinfecting properties.

Chemicals should effectively combat multiple types of microorganisms rapidly (meaning you don’t need to spray them on and let them sit to truly get your surface clean; they act quickly). We already mentioned this, but it’s important, so we’ll say it again: be sure nothing the disinfectant could contact could deactivate its disinfectant properties. Also, the disinfectant should be able to tolerate the temperatures of your cleanroom, should not damage any of your materials, and should be safe to use.

Common Solutions

The above restrictions and the vast amount of solutions on the market can make it feel like you’re trying to fit a square peg in a round hole when picking cleanroom cleaning solutions. However, there are several common solutions that’ll do trick, and knowing what those are will help you narrow your search.

Note that all the solutions mentioned below refer to the cleanroom-grade versions. They should come with sterility certificates and should be packaged in sterile bags, ready for cleanroom use.

Here are the six most common cleanroom cleaning solutions to get your hunt started:


  1. Cleanroom-Grade Isopropyl Alcohol
    This is a fairly obvious choice. We’ve all been using isopropyl alcohol to disinfect thermometers and the like for most of our lives. You should also consider looking for a version of this solution that comes in an aerosol mist so you can effectively sterilize hard to wipe surfaces like gloves and grates.
  2. Cleanroom-Grade Sporicide
    If your cleanroom requires a sterile chemical to kill spores, a cleanroom-grade sterile sporicide is the way to go. However, you can also find non-sterile cleanroom-grade sporicides, so be sure you know what you need and what you’re getting.
  3. Cleanroom-Grade Hydrogen Peroxide
    Hydrogen peroxide is great because it evaporates into water and oxygen, leaving no residue behind. Its toxic levels are also very low, and it’s non-flammable, so it’s a safe option.
  4. Cleanroom-Grade Quaternary Ammonium
    Like the sporicide, this solution also comes in sterile and non-sterile versions, so pay close attention to what you’re getting. The sterile version is not safe for food contact, so be sure you don’t use it in any cleanrooms where consumable products are manufactured.
  5. Cleanroom-Grade Sodium Hypochlorite Bleach
    Like alcohol and peroxide, bleach is a household product, but this cleanroom version packs a little extra punch. Again, this powerful cleaner comes in sterile and non-sterile versions, so make sure you know what you’re getting.
  6. Cleanroom-Grade Water
    You read that right – there’s such a thing as sterile water! This can be used for general wipe-downs or rinses or to dilute other solutions.

The six solutions listed above have only begun to scratch the surface of the cleanroom cleaning solutions that are available. Then, once you know which solutions you need, you still have several decisions to make. Do you need gallons or spray bottles? Do you want the concentrated or diluted version? Sterile or non-sterile? The list goes on.

Don’t tackle these choices alone. Hire a proven agency trained in cleanroom cleaning to help ensure you’re using the right cleanroom cleaning solutions for every situation so your organization stays compliant with regulations and standards.

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